MYC Amplification as a Potential Mechanism of Primary Resistance to Crizotinib in ALK-Rearranged Non-Small Cell Lung Cancer: A Brief Report

INTRODUCTION: Translocations of the anaplastic lymphoma kinase (ALK) can be effectively targeted in advanced non-small cell lung cancer by ALK-TKI inhibitors including Crizotinib.However, the development of acquired resistance often limits the duration of these therapies.While several mechanisms of secondary resistance have been already identified,

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In the Memory of Joseph Beuys: An Exhibition from the 1980s and Its Impact on the Izmir Contemporary Art Scene

In the 1980s, one of the most important debates in the arts and culture scene in Turkey is the commercialization of art.One of the results of the commercialization of art is the transformation of the work of art into a decorative object.As a solution to this problem, instead of a work of art produced by traditional mediums, an artistic practice out

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INSTITUTIONAL PROBLEMS REGARDING THE INTERACTION BETWEEN MONETARY AND FISCAL POLICY IN THE CONTEXT OF TARGETING INFLATION

In this work, the nature of the mutual influence of monetary and fiscal policy on one of the key problems Beach Shorts of the macroeconomic equilibrium of the economy of the Republic of Armenia and the accuracy of forecasting in the context of the application of policies targeting inflation is investigated.The problem of coordination between the tw

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